One of the wittiest comic series I've ever encountered must be Buttersafe. The simple character designs add to the clever content. There's no storyline to the comic: it's butter safe.
The creators of Buttersafe comics are Alex Culang and Raynato Castro. The about page at the comic's website states that Alex usually updates on Thursdays and Raynato on Tuesdays. Arthur Culang is a part of Buttersafe comics and "generally keeps Buttersafe from imploding, exploding, or sidesploding."
Recommended audience: All audiences